Occupational exposure to lead among fire assay workers in quality control laboratory normally impact greater to workers who actively contact with lead in metal analysis processes including activities like chemical preparation and fire assay process. Based on the measurement result of Pb concentration, the mean exposure to Pb in fire assay laboratory workers is 0.04 mg/m3, with the average personal intake of lead is obtained at 0.018 mg/m3. Threshold limit values (TLV) for chemical factor in workplace based on Ministry of Manpower and Transmigration of Republic of Indonesia Regulation Number PER.13/MEN/X/2011 about of 0.05 mg/m3, and thus the results of this research is still below the stated threshold limit value. Cumulatively, fire assay workers are still in the range of the reference interval 0 μg/dl to 14 μg/dl, although there is a gradual increase in PbB concentrations counted from 2012 until 2015. Regular maintenance of the ventilation system, monitoring the health of workers, job rotation and compliance to work safety procedures are among others very important in the effort and action to prevent and reduce their exposure.